Traditional Medicine 2022 | Traditional treatment is better for iron-deficiency anemia, clinical trial shows

Iron-deficiency anemia is the most common blood condition in the world. In the United States, it affects up to 3 percent of children between 1 and 2 years of age," said first author Dr. Jacquelyn Powers, assistant professor of pediatrics-hematology at Baylor College of Medicine and Texas Children's Cancer and Hematology Centers. "If the condition is not treated effectively, it can cause short- and long-term neurodevelopmental problems in children. In my practice, I noticed the lack of strong experimental data supporting how we treat these patients with oral iron therapy. In addition, there is a lot of variability in the practices between institutions nationwide, so I wanted to conduct a project that looked into this to help these patients.

We expected the newer medication, the iron polysaccharide complex, would restore the hemoglobin more effectively because it was designed to have improved taste and be tolerated better, and this might help patients to stick to the treatment," Powers said. "But the results surprised me; ferrous sulfate, the traditional medication, treated iron-deficiency anemia more effectively in our trial. The results of the trial also show that a low dose can treat the anemia effectively, and that the adverse gastrointestinal effects, such as abdominal pain, constipation, vomiting and diarrhea, were no different between the two treatments. Our trial provides pediatricians with evidence that one daily low dose of ferrous sulfate drops at bedtime on an empty stomach is a better treatment for young patients with iron-deficiency anemia.

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