Changes in how cholesterol breaks down in the body may accelerate progression of dementia

The blood-brain barrier is impermeable to cholesterol, yet high blood cholesterol is associated with increased risk of Alzheimer's disease and vascular dementia. However, the underlying mechanisms mediating this relationship are poorly understood. A new study suggests that disturbances in the conversion of cholesterol to bile acids may play a role in the development of dementia.

Little is known about how high blood cholesterol may lead to an increased risk of Alzheimer's and dementia, yet understanding the underlying processes may lay the foundation for discovering effective therapeutics. To investigate whether abnormalities in cholesterol catabolism through its conversion to bile acids is associated with development of dementia, researchers drew on more than 1800 participants from two prospective studies: the Baltimore Longitudinal Study of Aging (BLSA) and the Alzheimer's Disease Neuroimaging Initiative (ADNI).

First, the research team investigated whether cholesterol catabolism was associated with brain abnormalities typical of Alzheimer's and vascular dementia. They next tested whether exposure to cholesterol medications that block bile acid absorption into the bloodstream was associated with an increased risk of dementia among more than 26,000 patients from general practice clinics in the United Kingdom. Finally, they examined 29 autopsy samples from the BLSA to determine whether people with Alzheimer's disease tend to have altered levels of bile acids in their brains.

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Their findings suggest that cholesterol catabolism and bile acid synthesis may impact dementia progression through sex-specific effects on brain signaling pathways. However, additional studies are needed as the research was limited by the relatively small numbers of autopsy samples. In addition, experimental studies are required to better understand the role of cholesterol breakdown in dementia

Now they are testing whether approved drugs for other diseases that may correct bile acid signaling abnormalities in the brain could be novel treatments for Alzheimer's disease and related dementias.These analyses are being pursued in the Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study.

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We are organizing the Vascular Dementia 2023 Conference and are glad to invite you to join the Conference as Speaker/Delegate. Below are the details of the Conference:-

Conference Name: 15th International Conference on Vascular Dementia

Theme: Tackling Dementia with Technology

Date: February 20-21, 2023

Venue: Paris, France

Registration: 699 Euro (may increase)

Kindly register through this link: Registration

Kindly let us know your interest in the conference before October 25, 2022.

Do not hesitate to ask queries either through mail or WhatsApp.

Thanks & Regards,

Agatha Clemens
Program Manager
Email- dementia@meetingsnexpo.com
WhatsApp- +44-7915638336

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